Glutamate dehydrogenase (GDH) is found in all living organisms and is responsible for the digestion of amino acids. In animals, GDH is controlled by a complex network of metabolites. For decades, it was unclear why the animals necessary regulations, but not to other realms. This was partially answered by the group that congenital hyperinsulinism fatal Stanley / hyperammonemia (HHS), is caused by the loss of part of this regulation. In this disorder, patients (usually children) to meet consumption of protein by the secretion of insulin, severe hypoglycemia, which often leads to death.
Using the atomic structures to understand the differences between animals and plants, Dr. Smith and his colleagues found that two compounds found naturally in green tea are able to compensate for this genetic disease in remote areas off GDH as compounds Green tea is administered orally. Smith Laboratory also used X-ray crystallography to determine the atomic structure of these compounds in green tea is associated with the enzyme. With this atom of information, waiting to be able to change these natural compounds to design and develop better drugs.
Interestingly, two other research groups have confirmed and extended these findings to show that the GDH blockage with green tea is very effective in killing the two different types of tumors, glioblastomas, an aggressive form of brain tumor, and disease tuberous sclerosis complex, a genetic disease causing non-malignant tumors to grow on a number of organizations.
"While these compounds in green tea is very safe and consumed by millions every day, they have several properties that make them difficult to use than the real drugs. However, our ongoing collaboration with Stanley Lab shows that there are natural compounds from plants that can control this deadly disease and the atomic structure in hand, can be used as a basis for further development of pharmaceuticals. "
Using the atomic structures to understand the differences between animals and plants, Dr. Smith and his colleagues found that two compounds found naturally in green tea are able to compensate for this genetic disease in remote areas off GDH as compounds Green tea is administered orally. Smith Laboratory also used X-ray crystallography to determine the atomic structure of these compounds in green tea is associated with the enzyme. With this atom of information, waiting to be able to change these natural compounds to design and develop better drugs.
Interestingly, two other research groups have confirmed and extended these findings to show that the GDH blockage with green tea is very effective in killing the two different types of tumors, glioblastomas, an aggressive form of brain tumor, and disease tuberous sclerosis complex, a genetic disease causing non-malignant tumors to grow on a number of organizations.
"While these compounds in green tea is very safe and consumed by millions every day, they have several properties that make them difficult to use than the real drugs. However, our ongoing collaboration with Stanley Lab shows that there are natural compounds from plants that can control this deadly disease and the atomic structure in hand, can be used as a basis for further development of pharmaceuticals. "
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